Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease
Musculoskeletal diseases are a major global health burden. Development of new bone-active therapies is hindered by limited understanding of the complex interactions between the cells and genes that regulate the skeleton. To unravel this complexity...
Read Full ArticleThe genetic architecture of trabecular bone score and association with fracture
Trabecular bone score (TBS) is a texture-based measurement derived from DXA scans, which describes the distribution of mineral across the vertebral bodies. Identifying its genetic determinants is crucial for enhancing understanding of its biological basis and clarifying its relationship with fracture risk...
Read Full ArticleSkeletal Gene Browser
This interactive platform is designed to integrate information from (i) a genome-wide association studies (GWAS) of bone mineral density (BMD), (ii) gene expression data from individual bone and marrow cells isolated from mice, and (iii) extensive skeletal phenotyping data from human and murine mutant databases. By triangulating information from these complementary datasets, this platform can help musculoskeletal researchers to systematically prioritise the most likely effector genes that control BMD and...
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